Abstract: Based on the heart anatomy,plate-shell theory and optimum working condition of heart valve,we simulated the human heart valve with computer graphics.Parametric geometric modeling of bio-valve is accomplished, and the approximate development of non-developable stereoscopic valve frame and valve leaf is presented.Non-basement bio-valve has been designed and manufactured according to the theoretical results.Its good property has been confirmed by measurement in vitro and clinical application in vivo.