Abstract: This paper introduces a new variational model,capable of performing registration and segmentation simultaneously.In the model a couple function is constructed to fuse the non-rigid registration information and the active contour model,based on the region information. Using this information an energy function is constructed.Through finding the extremum of the energy function the model can realize registration and segmentation simultaneously. The model can be applied to analyze the images from different modals.The results of experiments show that the model can be employed to obtain better results robustly.